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The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis

ScholarsArchive at Oregon State University

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Title The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis
Names Ochieng, Josiah (creator)
Nangami, Gladys N. (creator)
Ogunkua, Olugbemiga (creator)
Bisson, William H. (creator)
et al. (creator)
Date Issued 2015-06 (iso8601)
Note This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Oxford University Press. The published article can be found at: http://carcin.oxfordjournals.org/
Abstract The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their
potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of lowdose
environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast
and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming
clearer that cancer stem cells in a tumor are the ones that assume invasive properties and colonize distant organs. Therefore, low-dose contaminants that trigger epithelial–mesenchymal transition, for example, in these cells are of particular interest
in this review. This we hope will lead to the collaboration between scientists who have dedicated their professional life to the
study of carcinogens and those whose interests are exclusively in the arena of tissue invasion and metastasis.
Genre Article
Identifier Ochieng, J., Nangami, G. N., Ogunkua, O., Miousse, I. R., Koturbash, I., Odero-Marah, V., ... & Eltom, S. E. (2015). The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis, 36(Suppl 1), S128-S159. doi:10.1093/carcin/bgv034

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