Record Details
Inhibiting the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2) enzyme with small molecules for the treatment of cancer
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | Inhibiting the Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2) enzyme with small molecules for the treatment of cancer |
| Names |
Rodgers, Brett
(creator) Bisson, William (advisor) |
| Date Issued | 2015-06-01 (iso8601) |
| Note | Bachelor of Science (BS) |
| Abstract | Based on recent findings, our hypothesis is that the inhibition of the Receptor tyrosine kinase-like orphan receptor 2 (ROR2) enzyme can lead to tumor suppression. ROR2 are trans-membrane proteins that are part of the receptor tyrosine kinase (RTK) family. ROR2 is generally not expressed in most normal adult tissues and represents a new target in the WNT signaling pathway. In order to test our hypothesis, we have developed a model using transiently transfected HEK-293T cells to screen for inhibition of ROR2-mediated downstream signaling. The inhibition of ROR2 activation, through canonical WNT pathway, will be studied by monitoring the level of activated-ROR2-induced phosphorylation of G-protein coupledreceptor Kinase 2 (GRK2) compared to untreated cells. The research proposed is significant because it will lead to novel lead compounds for multiple tumor types. |
| Genre | Poster |
| Topic | ROR2 |
| Identifier | http://hdl.handle.net/1957/55915 |
