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Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies: A Guide for Investigators, Authors, Reviewers, and Readers

ScholarsArchive at Oregon State University

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Title Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies: A Guide for Investigators, Authors, Reviewers, and Readers
Names Wolf, Jeffrey C. (creator)
Baumgartner, Wes A. (creator)
Blazer, Vicki S. (creator)
Kent, Michael L. (creator)
Spitsbergen, Jan M. (creator)
et al. (creator)
Date Issued 2015-04 (iso8601)
Note To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Sage Publications. The published article can be found at: http://tpx.sagepub.com/.
Abstract Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data.
Genre Article
Topic artifacts
Identifier Wolf, J. C., Baumgartner, W. A., Blazer, V. S., Camus, A. C., Engelhardt, J. A., Fournie, J. W., ... & Wolfe, M. J. (2015). Nonlesions, Misdiagnoses, Missed Diagnoses, and Other Interpretive Challenges in Fish Histopathology Studies A Guide for Investigators, Authors, Reviewers, and Readers. Toxicologic Pathology, 43(3), 297-325. doi:10.1177/0192623314540229

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