Record Details
Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures |
| Names |
Lee, Seung-Tae
(creator) Muench, Marcus O. (creator) Fomin, Marina E. (creator) Houseman, E. Andres (creator) et al. (creator) |
| Date Issued | 2015-03-11 (iso8601) |
| Note | This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Oxford University Press on behalf of Nucleic Acids Research. The published article can be found at: http://nar.oxfordjournals.org/. |
| Abstract | We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators. |
| Genre | Article |
| Access Condition | http://creativecommons.org/licenses/by/3.0/us/ |
| Identifier | Lee, S. T., Muench, M. O., Fomin, M. E., Xiao, J., Zhou, M., de Smith, A., ... & Wiemels, J. L. (2015). Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Research, 43(5), 2590-2602. doi:10.1093/nar/gkv103 |
