Record Details
In Situ Gelling Polyvalerolactone-Based Thermosensitive Hydrogel for Sustained Drug Delivery
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | In Situ Gelling Polyvalerolactone-Based Thermosensitive Hydrogel for Sustained Drug Delivery |
| Names |
Mishra, Gyan P.
(creator) Kinser, Reid (creator) Wierzbicki, Igor H. (creator) Alany, Raid G. (creator) Alani, Adam W. G. (creator) |
| Date Issued | 2014-10 (iso8601) |
| Note | This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at: http://www.journals.elsevier.com/european-journal-of-pharmaceutics-and-biopharmaceutics/ |
| Abstract | Biodegradable poly(ethyleneglycol)-poly(valerolactone)-poly(ethyleneglycol) [PEG-PVL-PEG] copolymers were synthesized through ring opening polymerization of δ-valerolactone (VL) followed by the coupling of monomethoxy poly(ethyleneglycol-poly(valerolactone) (mPEG-PVL) with hexamethylene diisocyanate (HDI). The copolymers were characterized by ¹H NMR, FT-IR, and GPC. Block copolymers of PEG and PVL with different VL/PEG molar ratios were successfully synthesized. One of the copolymers (Copolymer 2, PEG₅₅₀-PVL₆₇₆₈-PEG₅₅₀) displayed a sol-gel transition at a physiological temperature based on the test tube inverting method and rheological studies. The thermogelling copolymer demonstrated a characteristic crystalline peak for PVL block as determined by DSC and XRD analysis. In vitro release from the copolymer hydrogel matrix indicated that dexamethasone (DEX), a hydrophobic model drug, released comparatively slower than 5-fluoruracil (5-FU), a hydrophilic model drug, due to the potential partitioning of DEX into the PVL core. 5-FU in vitro release from copolymer 2 was 86% in 22 hr, whereas only 14% of DEX was released in 24 hr. Cell viability studies confirmed that hydrogels composed of block copolymers are biocompatible. Copolymer 2 showed more than 80% relative cell viability at all concentrations, including concentrations greater than 200 fold CMC. In vivo gel formation studies indicate that gel integrity was maintained for 7 days upon subcutaneous injection into mice. These results indicate that PEG-PVL-PEG copolymers are suitable for drug delivery applications. |
| Genre | Article |
| Topic | δ–valerolactone |
| Identifier | Mishra, G. P., Kinser, R., Wierzbicki, I. H., Alany, R. G., & Alani, A. W. G. (2014). In situ gelling polyvalerolactone-based thermosensitive hydrogel for sustained drug delivery. European Journal of Pharmaceutics and Biopharmaceutics, 88(2), 397-405. doi:10.1016/j.ejpb.2014.06.004 |
