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Studies on copper metabolism in the cotton rat Sigmondon hispidus texianus

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Field Value
Title Studies on copper metabolism in the cotton rat Sigmondon hispidus texianus
Names Milne, David Bayard (creator)
Haag, J. R. (advisor)
Date Issued 1965-01-15 (iso8601)
Note Graduation date: 1965
Abstract The effects of different levels of copper in the diet on growth
rates, blood and liver copper concentrations, hemoglobin levels,
and cytochrome c oxidase activities were determined in the cotton
rat. The response of the cotton rat to different levels of copper was
analagous to that of the common laboratory rat. The blood and liver
copper patterns followed a course similar to that of most species
fed different levels of copper. Six and one half parts per million
copper were assumed to approximate "normal" copper levels, while
the 1.5 ppm level was definitely subnormal. The 50 ppm copper
level appeared to approach the toxic level, even though some copper
dependent functions were stimulated in this latter group. Copper in
concentrations of over 1.5 ppm was needed for better growth, hemoglobin
formation, and normal pigmentation. When the cotton rat
was given excessive amounts of copper, these functions, with the
exception of hair pigmentation, were depressed slightly. The
cytochrome oxidase activity in cotton rats was not demonstrated to
be significantly influenced by different levels of copper in the diet.
Genre Thesis/Dissertation
Topic Copper -- Metabolism
Identifier http://hdl.handle.net/1957/48384

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