Record Details
The effect of azetidine-2-carboxylic acid on proline biosynthesis in Escherichia coli
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | The effect of azetidine-2-carboxylic acid on proline biosynthesis in Escherichia coli |
| Names |
Smith, Faith Irene
(creator) Baich, Annette (advisor) |
| Date Issued | 1967-03-10 (iso8601) |
| Note | Graduation date: 1967 |
| Abstract | The effect of the proline analogue, L-azetidine-2-carboxylic acid, on proline biosynthesis in Escherichia coli has been studied. The analogue inhibits the formation of proline precursor by acting as a false feedback inhibitor, Analysis of kinetic constants in whole-cell preparations indicate that the inhibition is noncompetitive. Comparative inhibitor constants for proline and azetidine-2-carboxylic acid are 5 x 10⁻⁷ M and 4 x 10⁻⁵ M, respectively. The latter constant has been corrected for the amount of inhibitor found in the bacterial cell. The structural specificity of the control mechanism is discussed. |
| Genre | Thesis/Dissertation |
| Topic | Escherichia coli |
| Identifier | http://hdl.handle.net/1957/47303 |
