Record Details
Size criterion for intercalation of hydrocarbon in DNA
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | Size criterion for intercalation of hydrocarbon in DNA |
| Names |
Craig, Albert Morrie
(creator) Isenberg, I. (advisor) |
| Date Issued | 1968-04-25 (iso8601) |
| Note | Graduation date: 1968 |
| Abstract | The binding of fifteen hydrocarbons to native DNA has been investigated. The hydrocarbons were chosen to test a size criterion for hydrocarbon - DNA complexes. It has been found that hydrocarbons, which are small enough to intercalate between the base pairs of a distorted Watson - Crick model of DNA, bind to DNA. No binding was found for hydrocarbons which cannot slip between base pairs, with no appreciable contact with the aqueous medium. Those hydrocarbons which bind, do so in a monomolecular fashion, as judged by the absence of excimer emission. The results are consistent with the intercalation model of binding and offer support for it. |
| Genre | Thesis/Dissertation |
| Topic | DNA |
| Identifier | http://hdl.handle.net/1957/47183 |
