Record Details
Aspects of ergosterol biosynthesis in Saccharomyces cerevisiae
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | Aspects of ergosterol biosynthesis in Saccharomyces cerevisiae |
| Names |
Monner, David Anthony
(creator) Parks, Leo W. (advisor) |
| Date Issued | 1968-04-30 (iso8601) |
| Note | Graduation date: 1968 |
| Abstract | The regulation of ergosterol biosynthesis in yeast has been studied. The system has been examined for the presence of an end-product inhibition. Both anaerobically and aerobically grown cells have been examined for this effect. A feedback inhibition of sterol synthesis has been shown, but it appears to be a secondary effect. The regulation is intimately involved with the carbohydrate metabolism of the aerobic cell. Other involvements may exist in anaerobic cells. A type of catabolite repression of ergosterol biosynthesis has been hypothesized. An inhibitor of sterol synthesis which is cationic in nature has been found in yeast extract. The inhibitory effect is directed specifically at transmethylation, and may cause the accumulation of precursors to transmethylation in ergosterol synthesis. A procedure has been developed for extracting sterols from cell-free extracts of yeast. The method gives larger and more consistent yields of sterol than the conventional methods of extraction. |
| Genre | Thesis/Dissertation |
| Topic | Saccharomyces |
| Identifier | http://hdl.handle.net/1957/46975 |
