Record Details
Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits
ScholarsArchive at Oregon State University
| Field | Value |
|---|---|
| Title | Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits |
| Names |
Megraw, Molly
(creator) Mukherjee, Sayan (creator) Ohler, Uwe (creator) |
| Date Issued | 2013 (iso8601) |
| Note | This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by BioMed Central Ltd. The published article can be found at: http://genomebiology.com/. Supporting Information can be found at: http://genomebiology.com/2013/14/8/R85/additional |
| Abstract | WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes. |
| Genre | Article |
| Access Condition | http://creativecommons.org/licenses/by/3.0/us/ |
| Topic | gene regulation |
| Identifier | Megraw, M., Mukherjee, S., & Ohler, U. (2013). Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits. Genome Biology, 14(8), R85. doi:10.1186/gb-2013-14-8-r85 |
